Metformin therapy for diabetes mellitus in Prader-Willi syndrome
نویسنده
چکیده
Prader-Willi syndrome (PWS) is a rare neurogenetic disorder, which occurs in l per 15,000 live-born children. First described in 1956 by doctors Prader, Labhart and Willi, it is the commonest cause of syndromic obesity in childhood. Diabetes mellitus (DM) is a rare complication of children with PWS. A literature search revealed that most PWS children with DM have required insulin as their treatment while only a couple have responded to oral hypoglycaemic drugs. We report a 11 year old girl with PWS complicated by DM treated with the oral hypoglycaemic drug metformin.
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